A tonic receptor is a sensory receptor that adapts slowly to a stimulus, while a phasic receptor is a sensory receptor that adapts rapidly to a stimulus. Learning Objectives Differentiate among the types of stimuli to which receptors respond.
Key Points Chemoreceptors detect the presence of chemicals. Thermoreceptors detect changes in temperature. Mechanoreceptors detect mechanical forces. Photoreceptors detect light during vision. More specific examples of sensory receptors are baroreceptors, propioceptors, hygroreceptors, and osmoreceptors.
Sensory receptors perform countless functions in our bodies mediating vision, hearing, taste, touch, and more. Key Terms photoreceptor : A specialized neuron able to detect and react to light.
Broadly, sensory receptors respond to one of four primary stimuli: Chemicals chemoreceptors Temperature thermoreceptors Pressure mechanoreceptors Light photoreceptors A schematic of the classes of sensory receptors : Sensory receptor cells differ in terms of morphology, location, and stimulus. Classification of Sensory Receptors Adequate Stimulus Adequate stimulus can be used to classify sensory receptors.
Other transmembrane proteins, which are not accurately called receptors, are sensitive to mechanical or thermal changes. Physical changes in these proteins increase ion flow across the membrane, and can generate an action potential or a graded potential in the sensory neurons.
Stimuli in the environment activate specialized receptor cells in the peripheral nervous system. Different types of stimuli are sensed by different types of receptor cells. Receptor cells can be classified into types on the basis of three different criteria: cell type, position, and function.
Receptors can be classified structurally on the basis of cell type and their position in relation to stimuli they sense. They can also be classified functionally on the basis of the transduction of stimuli, or how the mechanical stimulus, light, or chemical changed the cell membrane potential.
The cells that interpret information about the environment can be either 1 a neuron that has a free nerve ending , with dendrites embedded in tissue that would receive a sensation; 2 a neuron that has an encapsulated ending in which the sensory nerve endings are encapsulated in connective tissue that enhances their sensitivity; or 3 a specialized receptor cell , which has distinct structural components that interpret a specific type of stimulus Figure 1.
Figure 1. Receptor Classification by Cell Type. Receptor cell types can be classified on the basis of their structure. Sensory neurons can have either a free nerve endings or b encapsulated endings. Photoreceptors in the eyes, such as rod cells, are examples of c specialized receptor cells.
These cells release neurotransmitters onto a bipolar cell, which then synapses with the optic nerve neurons. The pain and temperature receptors in the dermis of the skin are examples of neurons that have free nerve endings.
Also located in the dermis of the skin are lamellated corpuscles, neurons with encapsulated nerve endings that respond to pressure and touch. The cells in the retina that respond to light stimuli are an example of a specialized receptor, a photoreceptor.
Another way that receptors can be classified is based on their location relative to the stimuli. An exteroceptor is a receptor that is located near a stimulus in the external environment, such as the somatosensory receptors that are located in the skin. An interoceptor is one that interprets stimuli from internal organs and tissues, such as the receptors that sense the increase in blood pressure in the aorta or carotid sinus.
Finally, a proprioceptor is a receptor located near a moving part of the body, such as a muscle, that interprets the positions of the tissues as they move. A third classification of receptors is by how the receptor transduces stimuli into membrane potential changes.
Stimuli are of three general types. Some stimuli are ions and macromolecules that affect transmembrane receptor proteins when these chemicals diffuse across the cell membrane. Some stimuli are physical variations in the environment that affect receptor cell membrane potentials. Other stimuli include the electromagnetic radiation from visible light. For humans, the only electromagnetic energy that is perceived by our eyes is visible light.
Some other organisms have receptors that humans lack, such as the heat sensors of snakes, the ultraviolet light sensors of bees, or magnetic receptors in migratory birds. Receptor cells can be further categorized on the basis of the type of stimuli they transduce. Osmoreceptors respond to solute concentrations of body fluids. Additionally, pain is primarily a chemical sense that interprets the presence of chemicals from tissue damage, or similar intense stimuli, through a nociceptor.
Physical stimuli, such as pressure and vibration, as well as the sensation of sound and body position balance , are interpreted through a mechanoreceptor. Another physical stimulus that has its own type of receptor is temperature, which is sensed through a thermoreceptor that is either sensitive to temperatures above heat or below cold normal body temperature.
Ask anyone what the senses are, and they are likely to list the five major senses—taste, smell, touch, hearing, and sight. However, these are not all of the senses. The most obvious omission from this list is balance. Also, what is referred to simply as touch can be further subdivided into pressure, vibration, stretch, and hair-follicle position, on the basis of the type of mechanoreceptors that perceive these touch sensations.
Other overlooked senses include temperature perception by thermoreceptors and pain perception by nociceptors. Within the realm of physiology, senses can be classified as either general or specific. A general sense is one that is distributed throughout the body and has receptor cells within the structures of other organs. Mechanoreceptors in the skin, muscles, or the walls of blood vessels are examples of this type.
General senses often contribute to the sense of touch, as described above, or to proprioception body movement and kinesthesia body movement , or to a visceral sense , which is most important to autonomic functions. A special sense is one that has a specific organ devoted to it, namely the eye, inner ear, tongue, or nose. Each of the senses is referred to as a sensory modality.
Modality refers to the way that information is encoded, which is similar to the idea of transduction. The main sensory modalities can be described on the basis of how each is transduced. The chemical senses are taste and smell. The general sense that is usually referred to as touch includes chemical sensation in the form of nociception, or pain.
Pressure, vibration, muscle stretch, and the movement of hair by an external stimulus, are all sensed by mechanoreceptors. Hearing and balance are also sensed by mechanoreceptors. Finally, vision involves the activation of photoreceptors. Listing all the different sensory modalities, which can number as many as 17, involves separating the five major senses into more specific categories, or submodalities , of the larger sense.
An individual sensory modality represents the sensation of a specific type of stimulus. For example, the general sense of touch, which is known as somatosensation , can be separated into light pressure, deep pressure, vibration, itch, pain, temperature, or hair movement. Only a few recognized submodalities exist within the sense of taste, or gustation.
This process is calcium-dependent and ultimately produces an increase in the melanogenesis enzymes tyrosinase and dopachrome tautomerase, though the phototransduction pathway leading to calcium mobilization remains unexplored Regazzetti et al. This discovery could have immediate clinical applications, as it suggests that patients with skin hyperpigmentation could benefit from using sunscreen against broad-spectrum UV supplemented with a filter for short-wavelength blue light Boukari et al.
Light therapy is currently being investigated for the treatment of acne. Several studies have shown the potential for LED-delivered light to have antibacterial and anti-inflammatory properties. More recently, nm blue light was found to suppress the proliferation of human primary sebocytes, and nm red light to strongly downregulate lipid production, though the mechanisms of phototransduction remain unknown Jung et al.
The recent discoveries of functional photoreceptors on the skin raise the possibility of other light-induced responses in deeper tissues. Although UV light does not penetrate into deep tissues, a small percentage of visible light does penetrate through the skin to varying depths proportional to its wavelength.
Indeed, a recent study on subcutaneous white adipose tissue, which plays an active role in the development of diabetes, obesity, and cardiovascular diseases, revealed that blue light induced an inward current on human and mouse adipocytes that was mediated by melanopsin, PLC, and TRP channels Ondrusova et al. Furthermore, daily exposure to blue light induced physiologic changes in the adipocytes, including reduced lipid storage, which could imply a light-induced protective mechanism.
Interestingly, studies have shown that light can affect human adipose-derived stem cells. Blue and green light increased intracellular calcium levels, halted proliferation, and promoted osteoblast differentiation, whereas red and near-infrared NIR light stimulated proliferation Wang et al.
Blue, green, and red light also produced different effects on freshly isolated human adipose tissue-derived stromal vascular fraction cells, which include adipose-derived stem cells.
Red light again promoted proliferation, and, interestingly, green and red light promoted vasculogenesis Wang et al. Although photorelaxation, the light-induced dilation of blood vessels, was first described in Furchgott et al. In that study the authors showed that photorelaxation was blue-wavelength-specific and that both pharmacologic inhibition and genetic knockdown of melanopsin Opn4 ablated the response in the mouse aorta.
Interestingly, the response was quickly desensitized, with vessels returning to their constricted state after continued light exposure. Incubation with a G protein coupled receptor kinase 2 GRK2 inhibitor prevented this desensitization and amplified photorelaxation, suggesting G-protein-mediated phototransduction. More recently, photorelaxation was also shown to involve Opn3 encephalopsin , as suppression of both Opn3 and Opn4 in mouse pulmonary artery almost completely abrogated blue wavelength — nm light-induced vascular relaxation Figure 2A.
Figure 2. Effects of light exposure on pulmonary artery relaxation. B Representative traces show pulmonary arterial pressure P PA of isolated perfused rat lungs subject to hypoxia-induced pulmonary hypertension HPV.
Reproduced with permission from Barreto Ortiz et al. In the presence of GRK2 inhibitor, blue light both reverted and prevented phenylephrine-induced constriction of isolated pulmonary arteries.
Furthermore, this treatment ablated single-cell constriction and reversed phenylephrine-induced depolarization of isolated pulmonary arterial smooth muscle cells. More importantly, a phototherapeutic treatment consisting of GRK2 inhibition plus exposure to blue light induced significant vasorelaxation of pulmonary arteries from rats with chronic pulmonary hypertension PH , even when traditional vasodilatory drugs had only a modest effect. Phototherapy also reduced pulmonary arterial pressure in the lungs of rats subject to acute hypoxia-induced PH Figures 2B,C , demonstrating the clinical potential of using phototherapy to treat vasoconstrictive diseases such as PH Barreto Ortiz et al.
It is now well known that opsins perform numerous non-image-forming functions, with perhaps the most well studied being photoentrainment and circadian rhythm regulation. In mammalian vertebrates, these functions are performed largely by opsins in the eye, as damage to the eyes ablates photoentrainment Nelson and Zucker, Photoentrainment is regulated both through light detection in rods and cones and through the effect of melanopsin in intrinsically photosensitive retinal ganglion cells ipRGCs Hannibal and Fahrenkrug, ; Panda et al.
More recently, neuropsin OPN5 was shown to be necessary for non-visual retinal photoentrainment in mammals, dictating molecular circadian rhythms ex vivo and revealing a role for what was until then an orphan photoreceptor Buhr et al. Despite the critical role of the eyes in mammalian photoentrainment, however, the CNS has been shown to play a crucial part in the photoreception that regulates circadian rhythm in a wide range of other animals.
In teleost fish and amphibians, for example, several photoreceptive sites have been identified outside the eyes, including the pineal complex, deep brain, and skin Peirson et al. In fact, the pineal complex has been the focus of several photoentrainment studies in non-mammalian vertebrates. In a variety of species, the expression of several opsins has been confirmed, including pinopsin — nm , vertebrate ancient opsin — nm , exorhodopsin nm , parapinopsin and nm bi-stable , teleost multiple tissue opsin, and parietopsin nm Peirson et al.
In zebrafish, the pineal gland contains an endogenous circadian pacemaker and expresses an opsin that is called exorhodopsin because of its similarity to rhodopsin Mano et al. Other opsins have been found in zebrafish deep brain Kojima et al. This finding suggests that deep brain opsins also have functions outside of photoentrainment, particularly during development. Indeed, other studies have confirmed the role of opsins during zebrafish embryogenesis and identified vertebrate ancient long opsin in the CNS as a regulator of light-induced motor behavior and neural activity.
Drosophila have an alternative entrainment pathway that is mediated by cryptochrome Cry. Cry is a blue-light-sensitive protein that was found to aid in Drosophila photoentrainment and suggested to provide an independent cell-autonomous response to light in ventral lateral brain neurons Emery et al. Because silencing of Cry did not completely eliminate circadian photoentrainment, researchers suspected that another photoreceptor also played a role.
A recent study revealed a seventh rhodopsin in Drosophila Rh7 that contributes to photoentrainment by circadian pacemaker neurons in the brain, mediating a direct response to violet light nm Ni et al. These discoveries in a wide variety of animals suggest an adaptation to environmental light in the CNS that might have been lost during mammalian evolution, might still be present as a vestigial system, or might actually remain active in humans and have potential clinical applications.
Encephalopsin was the first opsin found outside of the ocular system in the mammalian brain Blackshaw and Snyder, Neuropsin also has been found in the human retina, brain, and testis Tarttelin Emma et al.
Melanopsin was also widely expressed at mRNA and protein levels in the human brain Nissil et al. Recent studies have shown that extraocular blue light delivered via the ear canals can influence human brain function and may have antidepressant effects Jurvelin et al.
Furthermore, low-level light therapy, recently renamed photobiomodulation, has been suggested to provide neuroprotection against Parkinson's and other neurodegenerative diseases, and to provide beneficial effects in wound healing after traumatic events and in psychiatric disorders Schiffer et al. The suggested mechanism of action entails increasing cytochrome oxidase and superoxide dismutase activities Rojas et al. Moreover, these studies prove that some light can penetrate the skull to produce physiologic responses in the human brain.
The OPN3 gene has been implicated in asthma for specific populations. It is expressed in the lung bronchial epithelia and in immune cells, suggesting that it may have a role in asthma susceptibility and immune response modulation White et al. How this response is modulated, however, has not been demonstrated. Interestingly, Yim et al. Perhaps more intriguing is the finding that opsins can serve a non-light-dependent sensing role. In it was discovered that Drosophila rhodopsin in fact mediates this response, as genetic silencing of the gene for this protein abolished the response, and introduction of mouse melanopsin restored normal thermotactic behavior Shen et al.
These findings oppose the dogma that opsin photoreceptors serve only to detect light and opens the possibility for unexplored physiologic functions. Mammalian sperm is extremely sensitive to temperature changes, and this study showed that opsins modulate temperature-induced movement of both mouse and human spermatozoa. Interestingly, encephalopsin, melanopsin, rhodopsin, and neuropsin were each found to be distinctly localized within specific regions of the spermatozoa.
In addition, ORs in the nose signal combinatorially; that is, rather than each scent being encoded by one neuron, a particular combination of neurons firing at the same time indicates a particular scent. Because of this, the system has the capacity to identify a massive number of odors; although the precise number of odors that humans can discriminate remains unknown, it has been estimated to be as high as 1 trillion Bushdid et al.
When an OR in an olfactory sensory neuron binds to its ligand, it activates an olfactory G-protein G olf , similar to G s , which subsequently activates adenylate cyclase 3 AC3 , leading to cAMP production. The resultant influx of cAMP activates cyclic nucleotide-gated channels, ultimately leading to a series of ion fluxes that produce an action potential. It is worth noting that animals which are null for either G olf or AC3 cannot smell Belluscio et al.
Because mice at birth are dependent on smell to nurse, these anosmic mice typically die shortly after birth. Here, we will briefly highlight what is known about the roles of human, murine, or rat receptors in each of the systems listed below, as summarized in Table 1.
To that end, in the text below we will refer to human ORs except when indicated otherwise; for murine and rat ORs, we will state whether or not a human ortholog is known. The earliest report of ORs in the airway Gu et al. The study showed that exposure of the lung epithelium to volatile chemicals activates PNECs, leading to changes in the secretion of compounds that affect neighboring cells.
Intriguingly, the data also suggested that these processes may be altered in chronic obstructive pulmonary disease. In , Chang et al. Chang et al. That study demonstrated that ligands for OR51E2 modulated proliferation and cytoskeletal remodeling and that these effects were dependent on OR51E2 expression.
Intriguingly, these effects occurred in ASM from individuals both with and without asthma. Finally, a study in examined a non-small-cell lung cancer cell line Kalbe et al. Furthermore, helional acts on OR2J3 to induce apoptosis and inhibit cell proliferation, implying that this pathway may have therapeutic benefit. A number of reports indicate that ORs play roles in a variety of cell types within the gastrointestinal system. To date, four reports have focused on enterochromaffin EC cells.
The authors of that study found that ligands for these ORs altered both calcium signaling and serotonin release Braun et al. Finally, a study from Kidd et al. Elsewhere in the gastrointestinal tract, researchers have investigated the role of OR51B4 in colorectal cancer. Weber et al. Finally, the mouse OR Olfr, which does not have a known human ortholog, has been examined for a potential role in the gastrointestinal tract.
In , one group showed that Olfr is expressed in alpha cells of mouse pancreatic islets, where it regulates glucagon secretion via calcium mobilization in response to its ligand, azelaic acid Kang et al. In , a second group showed that Olfr is expressed in liver and adipose tissue, where the authors proposed it contributes to a shift in fuel preference toward fats Wu et al.
The first functional example of an OR expressed outside of the nose was a report in showing that OR was expressed in human sperm. The authors suggested that the ligand for this OR bourgeonal may help direct the sperm in the direction of the egg to aid in fertilization Spehr et al.
This landmark study was followed by a series of studies from the same group examining not only the role of OR Spehr et al. Finally, it has also been shown that ORs are expressed in the kidney and play functional roles in renal function. A study in reported that several ORs, along with G olf and AC3, are expressed in the murine kidney, and that G olf and AC3 localize to the macula densa a chemosensory cell type Pluznick et al.
Subsequently, it was reported that Olfr78 the murine ortholog of OR51E2 localizes to juxtaglomerular cells in the kidney, where it acts to modulate renin secretion Pluznick et al. Olfr a murine OR without a clear human ortholog was reported to be expressed in renal proximal tubule cells, where it influences glucose handling.
Shepard et al. A number of other ORs and taste receptors have been identified in murine kidney Rajkumar et al. ORs have been found in blood cells, where they are associated with tauopathy Zhao et al. In addition, OR10J5 has been reported to play a role in angiogenesis it is expressed in human aorta and coronary artery, as well as an endothelial cell line Kim et al. Another group reported that myocardial function is modulated via activation of an odorant receptor, OR51E1 Jovancevic et al.
In , it was reported that exposure to odorants such as Sandalore induced ATP release from keratinocytes and thereby signaled to trigeminal neurons, implying that keratinocytes must have a way to sense the odorant Sondersorg et al. These findings led to the hypothesis that OR2AT4 may play a role in wound healing. In , it was shown that a soluble ligand for MOR23 is secreted by muscle cells and that loss of MOR23 leads to increased myofiber branching Griffin et al.
Subsequently, in , the same group published work in which a transgenic mouse for MOR23 was crossed with dystrophic mice. They found that mechanical stress caused less damage to muscles from MORoverexpressing dystrophic mice than to those from control dystrophic mice Pichavant et al. OR51E2 has been reported to play a role in regulating cell growth of retinal pigment epithelial cells Jovancevic et al.
A landmark study in used next generation sequencing to profile the expression of ORs in 16 human tissues. The authors found that all tissues examined expressed at least one OR Flegel et al. In a similar vein, researchers in generated a novel antibody for Olfr murine OR with no clear human ortholog and found that it is expressed in a number of different cell types, including vascular endothelium, smooth muscle, and migrating neural crest Baker et al.
Thus, it is clear that ORs are expressed in additional cell types and tissues where their functions have yet to be uncovered. Sensory receptors are located in many different tissue types and their expression and function are altered during disease states.
Thus, they may represent new therapeutic targets for treating and altering disease progression. Many disease processes throughout the body have the potential to be treated with TAS2R agonists. TAS2R function in the upper airway has been well characterized.
TAS2Rs in mucociliary epithelial cells of the upper airway and nasal tissue appear to be directly involved in sinus disease.
Patients with chronic rhinosinusitis who have gene allelic frequencies favoring dysfunctional TAS2R38 are at higher risk for sinus surgery than those who are homozygous for functional TAS2R38 alleles Lee and Cohen, b ; Adappa et al. Bitterness inhibits hunger. Activation of enteroendocrine cells via TAS2Rs results in increased ghrelin levels, acutely increasing food intake; however, it also leads to decreased gastric emptying, which, in mice, decreases food intake in the long term Janssen et al.
In addition, bitter agonists administered to the stomach activate the nucleus tractus solitarii, and via vagal nerve activation, slow gastric emptying in human volunteers. Glendinning et al. Activation of TAS2Rs leads to smooth muscle relaxation in many different tissue types, providing therapeutic targets to treat diseases like pulmonary hypertension, reactive airway disease including asthma , and bladder spasms.
Studies showing vascular relaxation are limited to vessels in the brain and gastrointestinal tract; however, additional studies should be conducted to determine changes to peripheral and cardiac vasculature.
Therefore their use presents high potential for side effects caused by unintended receptor activation. Future research should focus on receptor-specific therapeutic medications to limit such effects. These receptors also contribute to progression of pathologic conditions, such as airway inflammation and asthma, and metabolic diseases of the pancreas, such as diabetes. The most significant role that TAS1Rs might have in the future is treatment for gastrointestinal diseases and obesity. In contrast to bitter receptor activation, sweet sensation promotes food intake.
Obesity decreases both bitter and sweet receptor expression in the duodenum and in areas of the murine brain involved in energy homeostasis. TAS1R3 is downregulated in the stomachs of obese patients Widmayer et al. These obesity effects suggest that TAS1R agonists may provide a therapeutic target to limit excess food intake. Like bitter taste receptors, TAS1Rs are also involved in bacterial recognition and immune cell function.
Stimulation of the innate immune response by altering sweet receptor expression may benefit those chronically infected or unresponsive to traditional anti-bacterial medications. These taste receptors may hold potential as therapeutic targets to treat these diseases, but this possibility requires investigation. The discovery of nonvisual opsins in non-classic sensory organs prompts us to question whether these receptors can be engaged for therapeutic potential.
The discovery that OPN4 receptors and TRPC channels in subcutaneous fat mediate a light-induced lipolytic activity suggests that blue-wavelength light might be used to reduce subcutaneous fat in a safe, noninvasive manner Ondrusova et al.
Since subcutaneous white adipose tissue is the main fat deposit in the human body, this could have big implications to aid in fat deposit regulation and the associated metabolic disorders.
Some applications of photoreceptors are already being explored for skin health, such as the use of directed light therapy on the skin to treat acne Jung et al. Regarding these applications, OPN3 has been suggested to take part in melanogenesis, but no known photoreceptor has been associated yet with the acne reduction in response to blue or red light.
Furthermore, blue light exposure was shown to have a positive effect on hair growth, an effect mediated by OPN3. These results suggest that exposure to blue light may be a safe treatment for alopecia Buscone et al.
The idea of using light to control the function of specific brain regions and to treat neurologic disorders has led to the field of optogenetics Deisseroth, Fiber-optic cables targeted to specific regions of the brain or other tissue can serve as the switch activators.
The limitations of this technology are 1 the need to transfect the light-activated switches using viral vectors and 2 the need for light-directing cables to be implanted in specific areas. With regard to the first limitation, the need for transfecting channels can be bypassed by recruiting the endogenously expressed OPNs in each tissue, or endogenous optogenetics.
The second limitation of using fiber optic cables can also be circumvented. Whereas blue light, the wavelength that activates the OPN3 and 4 receptors, has very limited tissue penetrance, NIR light has the potential for deep tissue penetration, including bone.
Upconverting nanocrystals, nanoparticles coated in rare earth lanthanides, can convert 2 photons of NIR light to 1 photon of blue light Christ and Schaferling, The delivery of these crystals in tissues might therefore allow the use of NIR light to stimulate and activate endogenous OPN receptors by up-conversion to blue light Chen et al. Given the expression of these OPN receptors in blood vessels and several brain tissues, this process may open up a potential light-based therapeutic path for the treatment of a wide variety of diseases.
As discussed previously, the phototherapeutic approach of using directed blue light delivery along with GRK2 inhibition can effectively induce sustained vascular relaxation by activating OPN3 and OPN4, while preventing receptor desensitization by GRK2. This treatment has been demonstrated to alleviate both chronic and acute PH in rat models, though its application could be extended to other cardiovascular diseases characterized by abnormal vasoconstriction Barreto Ortiz et al.
Additionally, this phototherapy has the potential of inducing vasodilation in acute vascular obstruction events easily and safely, possibly buying precious time for a patient experiencing a cardiovascular episode such as a stroke or heart attack and allowing blood flow to the affected areas until surgical procedures to remove the obstruction can be performed.
Further research on the clinical applicability of phototherapy in vascular relaxation is therefore crucial. As ORs comprise the largest gene family in the genome, opportunities likely exist to leverage these receptors to modify physiologic and pathophysiologic processes.
Such aspirations are currently limited by the fact that many ORs remain orphan receptors, with no known ligand. Because the most obvious strategy for commandeering these receptors for therapy would be to use agonists or antagonists, it is necessary that ligands be clearly identified for each of the ORs.
Although past efforts to identify ligands have been hampered by technical hurdles regarding OR trafficking in vitro , recent studies have made progress in this area Saito et al. ORs may lend themselves to being leveraged therapeutically in several potential areas, but we should caution that in all areas, future work is warranted to establish the feasibility and efficacy of potential interventions. OR51E2 has been shown to modulate proliferation and cytoskeletal remodeling in ASM from both asthmatics and non-asthmatics, implying that modulation of OR51E2 signaling may be beneficial in asthma Aisenberg et al.
A number of studies in several different systems have pointed to a potential role of ORs in controlling the growth of cancer cells. Hence, modulating OR signaling might offer the possibility to inhibit cancer cell growth. However, the same OR has also been shown to stimulate cancer cell invasiveness Sanz et al.
In addition, OR2J3 activation induced apoptosis and inhibited cell proliferation in a non-small-cell lung cancer cell line Kalbe et al. Olfr has been reported to play a role in the regulation of glucagon secretion Kang et al. In addition, Olfr modulates renal glucose handling by modulating Sglt1 Shepard et al. Of note, Sglt1 is similar in function to Sglt2, a current drug target used to reduce blood glucose in type 2 diabetes.
The suggestion that bourgeonal may act through an OR to help direct the sperm in the direction of the egg to aid in fertilization Spehr et al. Olfr78 increases renin secretion by the kidney and also plays a role in modulating vascular tone Pluznick et al. Activation of OR51E1 has been associated with negative chronotropic and inotropic effects on the heart Jovancevic et al.
Activation of OR2AT4 has been shown to promote cell proliferation and migration in keratinocytes Busse et al. When transgenic mice for MOR23 were crossed with dystrophic mice, mechanical stress caused less damage to the muscles from dystrophic mice with elevated MOR23 than to muscles from dystrophic mice with normal MOR23 levels Pichavant et al.
In conclusion, receptors traditionally believed only to identify and interpret light, sound, and taste also contribute to normal functions within many if not all other organ systems. Determining the function of sensory receptors in these organ systems and their roles under normal and pathophysiologic conditions has become a primary research focus with the potential to identify novel therapeutic targets to treat and possibly cure many medical diseases.
DB edited the final manuscript, contributing sections for novel therapeutic potential. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Adappa, N. T2R38 genotype is correlated with sinonasal quality of life in homozygous DeltaF cystic fibrosis patients. Forum Aller. Adler, E. A novel family of mammalian taste receptors. Cell , — Aisenberg, W.
Defining an olfactory receptor function in airway smooth muscle cells. An, S. Lung Cell. Ansoleaga, B. Neuroscience , — Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia. Avau, B. Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation.
Baker, N. Olfr, an orphan olfactory receptor, is expressed in multiple specific embryonic tissues. Gene Expr. Barreto Ortiz, S. Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition.
Bellono, N. UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Belluscio, L. Mice deficient in G olf are anosmic. Neuron 20, 69— PubMed Abstract Google Scholar. Blackshaw, S. Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain. J Neurosci. Boll, P. On the anatomy and physiology of the retina. Vision Res. Boukari, F. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial.
Braun, T. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology , — Buck, L. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.
Cell 65, — Buhr, E. Neuropsin OPN5 -mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. A , — Buscone, S. A new path in defining light parameters for hair growth: discovery and modulation of photoreceptors in human hair follicle.
Lasers Surg. Bushdid, C. Humans can discriminate more than 1 trillion olfactory stimuli. Science , — Busse, D. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. Cao, W.
Prostate specific G protein coupled receptor is associated with prostate cancer prognosis and affects cancer cell proliferation and invasion. BMC Cancer Chang, A. Oxygen regulation of breathing through an olfactory receptor activated by lactate. Nature , — Chao, D.
Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem. Sci Rep.
0コメント